MAPK signaling pathway and erectile dysfunction.
- Author:
Si-Xiang CHEN
1
;
Fan ZHAO
1
;
Xiao-Jun HUANG
2
Author Information
1. The Second School of Clinical Medicine, Zhejiang University of Chinese Medicine, Hangzhou, Zhejiang 310053, China.
2. Department of Urology, The Second Hospital Affiliated to Zhejiang University of Chinese Medicine, Hangzhou, Zhejiang 310005, China.
- Publication Type:Journal Article
- Keywords:
c-Jun N-terminal kinase;
extracellular signal-regulated kinase;
mitogen-activated protein kinase;
p38 mitogen-activated protein kinase;
erectile dysfunction
- MeSH:
Apoptosis;
Cell Differentiation;
Cell Proliferation;
Erectile Dysfunction;
etiology;
metabolism;
Humans;
JNK Mitogen-Activated Protein Kinases;
metabolism;
MAP Kinase Signaling System;
Male;
Mitogen-Activated Protein Kinases;
metabolism;
Signal Transduction;
p38 Mitogen-Activated Protein Kinases;
metabolism
- From:
National Journal of Andrology
2018;24(5):442-446
- CountryChina
- Language:Chinese
-
Abstract:
The MAPK signaling pathway plays a key role in the differentiation, proliferation and apoptosis of cells, and its family members mainly include extracellular signal-regulated kinase (ERK), stress-activated protein kinase (JNK), and p38 mitogen-activated protein kinase (p38MAPK). Recent studies have shown that the ERK, JNK and p38MAPK signaling pathways are closely associated with the development and progression of erectile dysfunction (ED). This review focuses on the correlation between the MAPK signaling pathway and ED.
