Immunological mechanisms of Neisseria gonorrhoeae infection: An update.
- Author:
Xue-Chun LI
1
;
Xiao-Hong SU
1
Author Information
1. Department of Sexually Transmitted Diseases, Research Institute of Dermatology, Peking Union Medical College, Chinese Academy of Medical Sciences, Nanjing, Jiangsu 210042, China .
- Publication Type:Journal Article
- Keywords:
adaptive immunity;
gonorrhea;
innate immunity;
Neisseria gonorrhoeae
- MeSH:
Adaptive Immunity;
Antibodies;
immunology;
Antigens, CD;
immunology;
Cell Adhesion Molecules;
immunology;
Complement Factor H;
immunology;
Gonorrhea;
immunology;
Humans;
Immune Evasion;
immunology;
Immunity, Innate;
immunology;
Neisseria gonorrhoeae;
immunology
- From:National Journal of Andrology
2018;24(5):452-456
- CountryChina
- Language:Chinese
-
Abstract:
Neisseria gonorrhoeae (NG), as a pathogen of gonorrhea, is strictly limited to growth on the human host. In case of gonococcal infection, the body may recruit such inflammatory cells as neutrophils to resist the invasion of NG or initiate its adaptive immune response by antigen presentation to eliminate the pathogen. However, a series of immune escape mechanisms of NG make it difficult to clear up the infection. In the innate immune system, NG can not only secrete thermonuclease to degrade neutrophile granulocytes, inhibit respiratory burst to resist killing by neutrophils, activate NLRP3 to prompt the pyronecrosis of inflammatory cells, but also regulate the differentiation of macrophages to reduce the inflammatory response, combine with factor H to evade complement-mediated killing. NG infection can hardly give rise to effective adaptive immune response and immune memory, but can promote TGF-β production to inhibit Th1/Th2-mediated adaptive immune response, bind to CEACAM1 on the B cell surface to promote apoptosis in B cells, and combine with CEACAM1 on the T cell surface to inhibit helper T cell proliferation, which makes it difficult for B cells to produce high-affinity specific antibodies. With the increasing drug-resistance of NG, immunological studies may play a significant role in the development of novel therapies and effective vaccines against the infection.
