Correlation of prostate-specific antigen with the progression and metastasis of human prostate cancer.
- Author:
Shu-Jiang ZHANG
1
;
Zu-Yue SUN
1
Author Information
1. Department of Pharmacology and Toxicology, Shanghai Institute of Planned Parenthood Research / National Evaluation Center for the Toxicology of Fertility-Regulating Drugs, Shanghai 200032, China.
- Publication Type:Journal Article
- Keywords:
cellular membrane receptor;
immunosuppression;
metastasis;
progression;
prostate cancer;
prostate-specific antigen;
serine protease activity
- MeSH:
Disease Progression;
Humans;
Male;
Neoplasm Metastasis;
Prostate-Specific Antigen;
physiology;
Prostatic Neoplasms;
pathology
- From:National Journal of Andrology
2018;24(5):457-461
- CountryChina
- Language:Chinese
-
Abstract:
Prostate-specific antigen (PSA) is a biomarker for the diagnosis and management of prostate cancer and involved in the development of prostate cancer and/or its progression from the localized to the metastatic stage. This review presents an overview of the roles of PSA in promoting the progression and metastasis of human prostate cancer and its underlying mechanisms, including its serine protease activity, interaction with the cellular membrane receptor, and suppression of specific immune responsiveness, and also points out some of the key problems to be solved.
