Clinical application of minimal residual disease detection in childhood acute leukemia.
- Author:
Yan-Qin CHENG
1
,
2
;
Xiao-Wen ZHAI
Author Information
1. Department of Hematology, Children&prime
2. s Hospital of Fudan University, Shanghai 201102, China. zhaoxiaowendy@163.com.
- Publication Type:Journal Article
- MeSH:
Hematopoietic Stem Cell Transplantation;
High-Throughput Nucleotide Sequencing;
Humans;
Leukemia, Myeloid, Acute;
diagnosis;
therapy;
Neoplasm, Residual;
diagnosis;
Precursor Cell Lymphoblastic Leukemia-Lymphoma;
diagnosis;
therapy;
Prognosis
- From:
Chinese Journal of Contemporary Pediatrics
2018;20(5):416-420
- CountryChina
- Language:Chinese
-
Abstract:
In recent years, great progress has been made in the treatment outcome of childhood acute leukemia with the improvement of chemotherapy regimens and the introduction of risk-stratified therapy; however, minimal residual disease (MRD) is still a difficult problem which affects the prognosis of acute leukemia. MRD influences the selection of chemotherapy regimens and recurrence risk stratification, and meanwhile, it can be used for prognostic prediction. At present, flow cytometry and polymerase chain reaction are mainly used for MRD detection. The next-generation sequencing also plays an important role in MRD detection, especially in MRD detection after stem cell transplantation. This article reviews the methodology and significance of MRD detection in childhood acute leukemia.
