Research advances in the role of aptamers in the diagnosis and targeted therapy of pediatric cancer.
- Author:
Yi-Bin ZHANG
1
;
Yan-Peng WANG
;
Jing LIU
Author Information
1. Molecular Research Center, School of Life Sciences, Central South University, Changsha 410078, China. jingliucsu@hotmail.com.
- Publication Type:Journal Article
- MeSH:
Child;
Early Detection of Cancer;
Humans;
Molecular Targeted Therapy;
Neoplasms;
diagnosis;
drug therapy;
SELEX Aptamer Technique;
methods
- From:
Chinese Journal of Contemporary Pediatrics
2018;20(5):421-427
- CountryChina
- Language:Chinese
-
Abstract:
Aptamers are single-stranded DNA or RNA which are isolated from synthesized random oligonucleotide library in vitro via systematic evolution of ligands by exponential enrichment (SELEX) and can bind to metal ions, small molecules, carbohydrates, lipids, proteins, and others targets with high affinity and specificity. Aptamers have the advantages of simple preparation, good thermal stability, and low immunogenicity and have great potential in the medical fields such as molecular imaging, biosensing, early diagnosis of diseases, and targeted therapy. Aptamer technology may be useful for early diagnosis and targeted therapy of pediatric cancer, and may avoid the side effects of conventional chemotherapy, such as growth and development disorders and long-term organ dysfunction. This article reviews the latest research advances in the selection and application of aptamers for pediatric cancer.
