Current status of the application of H-magnetic resonance spectroscopy in neonates with hypoxic-ischemic encephalopathy.
- Author:
Rong ZOU
1
;
Jun TANG
;
Shan BAO
;
Tian WU
;
Jing-Lan HUANG
;
Yi QU
;
De-Zhi MU
Author Information
- Publication Type:Journal Article
- MeSH: Female; Humans; Hypoxia-Ischemia, Brain; diagnosis; diagnostic imaging; Infant, Newborn; Infant, Newborn, Diseases; diagnosis; diagnostic imaging; Magnetic Resonance Imaging; methods; Male
- From: Chinese Journal of Contemporary Pediatrics 2018;20(6):449-455
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the current status of the application of H-magnetic resonance spectroscopy (H-MRS) in neonates with hypoxic-ischemic encephalopathy (HIE), and to describe the trend of research in the field.
METHODSPubMed, EMBASE, and Web of Science were searched for English articles published up to January 10, 2018, with the combination of key words and MeSH terms. The articles were screened according to inclusion and exclusion criteria. Excel 2016, Bicomb 2.0, and VOSviewer1.6.6 were used to analyze the key words, to perform a cluster analysis of hot words, and to plot the knowledge map.
RESULTSA total of 66 articles were included, and 27 high-frequency key words were extracted. The results showed that H-MRS was mainly used in four directions of the clinical practice and scientific research on HIE. In clinical practice, H-MRS attracted wide attention as a clinical examination for HIE and a tool for prognostic evaluation; in scientific research, H-MRS was used in animal experiments and studies associated with mild hypothermia therapy.
CONCLUSIONSAs an auxiliary means of magnetic resonance imaging, H-MRS plays an important role in investigating the pathogenesis of neonatal HIE, improving existing therapies, and evaluating the prognosis of neonates with HIE.
