Changes in T helper lymphocytes and their subsets in children with tic disorders.
- Author:
Xiao-Jun HOU
1
;
Shan LIN
;
Xiang-Quan LIN
;
Lin-Juan HUANG
;
Qiao-Yan HUANG
Author Information
- Publication Type:Journal Article
- MeSH: Child; Child, Preschool; Female; Flow Cytometry; Humans; Lymphocyte Count; Male; T-Lymphocyte Subsets; immunology; T-Lymphocytes, Helper-Inducer; immunology; Th1 Cells; immunology; Th2 Cells; immunology; Tic Disorders; genetics; immunology
- From: Chinese Journal of Contemporary Pediatrics 2018;20(7):519-523
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the changes in T helper lymphocytes and their subsets in children with tic disorders (TD) and their clinical significance.
METHODSFlow cytometry was used to measure the percentages of T helper lymphocytes and their subsets in the peripheral blood of children with TD and healthy children (controls).
RESULTSThe percentage of T helper lymphocytes was significantly lower in the TD group than in the control group (P<0.001). The abnormal rate of T helper lymphocytes in the TD group was significantly higher than that in the control group (68.7% vs 18.8%; P<0.001). The percentage of T helper lymphocytes was negatively correlated with Yale Global Tic Severity Scale score (r=-0.3945, P<0.001). As for the subsets of T helper lymphocytes, the TD group had a significantly higher percentage of Th1 cells and a significantly lower percentage of Th2 cells compared with the control group (P<0.001).
CONCLUSIONSThe abnormality of T helper lymphocytes and the imbalance of their subsets may be associated with the pathogenesis of TD in children. The percentage of T helper lymphocytes can be used as an indicator for assessing the severity of TD.
