Expression of Cyclin A, B1, D1, D3, and E in Non-Small Lung Cancers.
- Author:
Seung Yeon HA
1
;
Han Kyeom KIM
;
Jung Soo IM
;
Hyun Yee CHO
;
Dong Hae CHUNG
;
Jungsuk AN
Author Information
- Publication Type:Original Article
- Keywords: Cyclins; Lung neoplasms; Squamous cell carcinoma; Adenocarcinoma
- MeSH: Adenocarcinoma; Carcinoma, Squamous Cell; Cell Cycle; Cell Proliferation; Cyclin A; Cyclin B1; Cyclin D1; Cyclin D3; Cyclin E; Cyclin-Dependent Kinases; Cyclins; DNA Replication; G1 Phase; Lung; Lung Neoplasms; Lymph Nodes; Neoplasm Metastasis
- From:Journal of Lung Cancer 2012;11(1):33-37
- CountryRepublic of Korea
- Language:English
- Abstract: PURPOSE: Cyclins, and their associated cyclin dependent kinases, regulate progression of the cell cycle through the G1 phase and into the S-phase during the DNA replication process. Cyclin E regulation is an important event in cell proliferation. Despite its importance, abnormalities of these genes and their protein products have yet to be found in lits asoociation with lung cancer. MATERIALS AND METHODS: The relationships between expression of cyclin A, cyclin B1, cyclin D1, cyclin D3, and cyclin E and clinicopathologic factors were investigated in 103 cases with non-small cell carcinomas, using immunohistochemical analysis. RESULTS: The positive immunoreactivity was observed in 51 cases (50%) for cyclin A, 33 cases (32%) for cyclin B1, 83 cases (81%) for cyclin D1, 19 cases (18%) for cyclin D3, and 11 cases (11%) for cyclin E. Expression of cyclin E was significant for lymph node metastasis (p=0.004, Chi-square test). There was no relationship between cyclin A, B1, D1, and E and histological typing, tumor size, lymph node metastasis, or pathological tumor, node and metastasis staging. CONCLUSION: These findings suggest that the expression of cyclin E played a role, to some degree, in the lymph node metastasis.
