Expression of Insulin-like Growth Factor Recepter Type I in CD34 Cells of Patients with Myelodysplastic Syndromes.

Qing-Xia ZHANG; Qi HE; Juan GUO; Feng XU; Zheng ZHANG; Lian-Ping YANG; Chun-Kang CHANG

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Expression of Insulin-like Growth Factor Recepter Type I in CD34 Cells of Patients with Myelodysplastic Syndromes.

Author: Qing-Xia ZHANG ¹ ; Qi HE ² ; Juan GUO ² ; Feng XU ² ; Zheng ZHANG ² ; Lian-Ping YANG ² ; Chun-Kang CHANG ³
Author Information

1. Department of Hematology,The East-Branch of Sixth People's Hospital,Shanghai Jiaotong University,Shanghai 201306,China.
2. Department of Hematology,The Sixth People's Hospital,Shanghai Jiaotong University,Shanghai 200233,China.
3. Department of Hematology,The Sixth People's Hospital,Shanghai Jiaotong University,Shanghai 200233,China. E-mail:changchunkang7010@aliyun.com.
Publication Type:Journal Article
MeSH: Antigens, CD34; Bone Marrow Cells; Chromosome Aberrations; Flow Cytometry; Humans; Myelodysplastic Syndromes; Somatomedins
From: Journal of Experimental Hematology 2018;26(3):849-853
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo explore the expression level of insulin-like growth facter (IGF-IR) in CD34 cells of patients with myelodysplastic syndromes(MDS).
METHODSFlow cytometry was used to detect the expression of IGF-IR in the CD34 cells of 100 MDS patients and 18 normal controls.
RESULTSThe average IGF-IR expression level in the CD34 cells of 100 MDS patients (41.0±28.1)% was statistically and significantly elevated in comparison with the corresponding level in normal controls(4.3±1.8)%,(P<0.0001). The average expression level of 22 cases in high-risk groups was very significantly increased, compared with that in 78 cases of low-risk groups[(66.5±27.8)% vs (34.5%±24.9)%](P<0.0001), and the average expression level in 23 patients with chromosome abnormality was very significantly increased in comparison with that in rest 77 patients [(56.0±30.9)% vs (36.9%±26.2)%](P<0.01).
CONCLUSIONThe over-expression of IGF-IR in CD34 cells of MDS patients suggests that the IGF-IR may involve in the origin, occurrence and progress. The average IGF-IR expression level is markedly elevated in high-risk groups and the patients who showed chromosome abnormality, this trend revealed that IGF-IR correlates with malignant clonal proliferation in MDS patients, thus providing a basis for their prognosis and outcome evaluation.