Research Progress on Metabolic Regulatory Mechanisms of Hematopoietic Stem Cells -Review.
10.7534/j.issn.1009-2137.2018.03.048
- Author:
Ya-Wen ZHANG
1
;
Hui CHENG
1
;
Tao CHENG
2
,
3
,
4
,
5
Author Information
1. State Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Disease Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China.
2. State Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Disease Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China
3. Center for Stem Cell Medicine, Chinese Academy of Medical Sciences, Tianjin 300020, China
4. Department of Stem Cell and Regenerative Medicine, Peking Union Medical College, Tianjin 300020, China
5. Collaborative Innovation Center for Cancer Medicine, Tianjin 300020, China. E-mail: chengtao@ihcams.ac.cn.
- Publication Type:Journal Article
- MeSH:
Bone Marrow;
Cell Differentiation;
Hematopoietic Stem Cells;
Oxidation-Reduction;
Reactive Oxygen Species
- From:
Journal of Experimental Hematology
2018;26(3):917-921
- CountryChina
- Language:Chinese
-
Abstract:
Hematopoietic stem cells (HSC) are a class of stem cells with self-renewal and multipotent differentiation into a variety of blood cells and are most thoroughly studied, maturely applied in the clinic adult stem cell. Function of HSC is closely associated with metabolic regulation. The metabolic state mainly maintains HSC living in hypoxic bone marrow microenvironment depending on glycolysis for energy metabolism, and keeping low reactive oxygen species (ROS) level. Proteins like Hif-1, FoxO3, ATM, PTPMT1 protect HSC from ROS injury, maintaining HSC in hypoxic state. In addition, glucose metabolism-related enzymes, glutamine, fatty acid oxidation, purine and amino acid metabolism also play important roles in metabolic regulation of HSC. In this review the research progress on metabolism regnlation mechanisms of HSC is summurized, focusing on the mechanisms releted with oxydation metabolism regulation, carbohydrate metabolism level, purine metabolism and aminoacide metabolism.
