Long Non Coding RNA RP11-69I8.3 Expression in Acute Leukemia and Its Cinical Significance.

Jia-jia SI; Wei-min Wang; Dan YU; Si-lin Gan; Fei-fei WU; Ling Sun; Ding-ming Wan; Xin-sheng Xie; Yan-fang Liu; Chong Wang; Hui Sun

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Long Non Coding RNA RP11-69I8.3 Expression in Acute Leukemia and Its Cinical Significance.

Author: Jia-Jia SI ¹ ; Wei-Min WANG ¹ ; Dan YU ¹ ; Si-Lin GAN ¹ ; Fei-Fei WU ¹ ; Ling SUN ¹ ; Ding-Ming WAN ¹ ; Xin-Sheng XIE ¹ ; Yan-Fang LIU ¹ ; Chong WANG ¹ ; Hui SUN ²
Author Information

1. Department of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province,China.
2. Department of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province,China.E-mail: sunhui371@medmail.com.cn.
Publication Type:Journal Article
MeSH: Acute Disease; Fusion Proteins, bcr-abl; Humans; Leukemia; RNA, Long Noncoding
From: Journal of Experimental Hematology 2018;26(4):978-983
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo investigate the expression of long non coding RNA RP11-69I8.3 in acute leukemia and its clinical significance.
METHODSlncRNA RP11-69I8.3 expression was detected by RT-PCR in bone marrow samples from 17 healthy controls, 32 newly diagnosed AML patients and 32 newly diagnosed ALL patients, and 25 ALL patients of complete remission after chemotherapy. Meanwhile, the clinical data were collected and the relation of lncRNA RP11-6918.3 expression with the clinical characteristics was analyzed.
RESULTSCompared with the control group, there was no significant difference in the expression of lncRNA RP11-69I8.3 in AML group(P>0.05). lncRNA RP11-69I8.3 lowly expressed in untreated ALL group(P=0.001). Compared with the de novo ALL group, lncRNA RP11-69I8.3 was highly expressed in complete remission ALL group (P<0.013). In 32 de novo ALL patients,the expression of lncRNA RP11-69I8.3 in children was significantly lower than that in adult(P=0.017). There was no correlation of the expression of lncRNA RP11-69I8.3 with the sex, WBC count, HB level, Plt count, LDH level, T or B type, ratio of bone marrow blast cell, BCR/ABL and WT1 fusion gene expression, chromosome karyotype, extramedullary infiltration, whether complete remission after one chemotherapy, whether relapse. In 26 B-ALL patients, there was no correlation between lncRNA RP11-69I8.3 and the immunophenotype.
CONCLUSIONThe expression of lncRNA RP11-69I8.3 in the untreated AML is not significantly different from the control group. lncRNA RP11-69I8.3 is low expressed in ALL group, highly expressed in ALL group with complete remission. In untreated ALL, the expression of lncRNA RP11-69I8.3 in children is significantly lower than that in adult. In B-ALL patients, the lncRNA RP11-69I8.3 is not relevant with the immunophenotype.