Analysis of Prognostic Factors for 96 Patients with Acute Lymphoblastic Leukemia.
- Author:
Zhao-Yang DU
1
;
Ru-Yu YANG
1
;
Chao LI
1
;
Li-Juan DUAN
2
Author Information
- Publication Type:Journal Article
- MeSH: Acute Disease; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Humans; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Remission Induction
- From: Journal of Experimental Hematology 2018;26(4):1005-1010
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the clinical characteristics and clinical prognostic factors of patients with acute lymphoblastic leukemia (ALL).
METHODSNinety-six ALL patients in our hospital from June 2012 to August 2014 were selected and their clinical data were collected. The related clinical data of patients were recorded, and the relation between clinical characteristics and therapeutic efficacy was analyzed. The COX analysis was used to reveal the risk factors affecting the patient's OS and DFS time.
RESULTSAmong 96 ALL patients, 65 patients achieved complete remission (CR) after treatment. The age, immunophenotype, central nervous system leukemia (CNSL) and peripheral blood WBC count correlated with complete remission (P<0.05). The age, WBC count, platelet level, immune typing and consolidation therapy were the prognostic factors (P<0.05), the 2 year OS rate was influenced by age, WBC count, CD34 and consolidation therapy (P<0.05), the 2 year DFS rate was influenced by age, CD34 and consolidation therapy (P<0.05).
CONCLUSIONAge, WBC counts, CD34 and consolidated treatment after remission are prognostic factors for ALL patients, which has guiding significance for clinical treatment of ALL.
