Cystic Changes in Intraabdominal Extrahepatic Metastases from Gastrointestinal Stromal Tumors Treated with Imatinib.
- Author:
Hyo Cheol KIM
1
;
Jeong Min LEE
;
Seung Hong CHOI
;
Heon HAN
;
Sam Soo KIM
;
Sang Hyun LEE
;
Joon Koo HAN
;
Byung Ihn CHOI
Author Information
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords: Gastrointestinal stromal tumor; Neoplasms, metastases; Abdomen, CT
- MeSH: Adult; Aged; Antineoplastic Agents/*therapeutic use; Contrast Media; Gastrointestinal Stromal Tumors/*pathology/surgery; Humans; Iohexol/*analogs & derivatives/diagnostic use; Liver Neoplasms/drug therapy/*radiography/secondary; Male; Middle Aged; Peritoneal Neoplasms/drug therapy/*radiography/secondary; Piperazines/*therapeutic use; Protein-Tyrosine Kinase/antagonists & inhibitors; Pyrimidines/*therapeutic use; Research Support, Non-U.S. Gov't; Retrospective Studies; Tomography, X-Ray Computed/methods
- From:Korean Journal of Radiology 2004;5(3):157-163
- CountryRepublic of Korea
- Language:English
- Abstract: OBJECTIVE: This study was undertaken for the purpose of describing the CT features of intra-abdominal extra-hepatic metastases from gastrointestinal stromal tumors in patients who were treated with imatinib. MATERIALS AND METHODS: Eleven patients with intra-abdominal extra-hepatic metastases from gastrointestinal stromal tumors, who were treated with imatinib between May 2001 and December 2003, were included in this study. The clinical findings and CT scans were retrospectively reviewed. The metastatic lesions were assessed according to the location, size (greatest diameter), attenuation, and the enhancing pattern before and after imatinib treatment. RESULTS: Prior to the treatment, the sizes and attenuation values of the metastatic lesions ranged from 5 to 20 cm and from 63 to 131 H, respectively. The metastatic lesions showed a heterogeneous enhancement pattern on the contrast-enhanced CT scans. After the treatment, the metastatic lesions became smaller in all 11 patients, and the corresponding attenuation value ranged from 15 to 51 H. The metastatic lesions became homogeneous and cystic in appearance on the follow-up CT scans, mimicking ascites. CONCLUSION: Intra-abdominal extra-hepatic metastases of patients with gastrointestinal stromal tumors treated with imatinib may appear as well-circumscribed cystic lesions on contrast-enhanced CT. These metastases are likely to become smaller and resemble ascites, but may persist indefinitely on the follow-up CT.
