Factors Related to Gemcitabine-induced Phlebitis

Akiko Unesoko; Akio Kohno; Nobukazu Tomita; Kiyoshi Ishigure; Ayumi Sugimura; Kazuki Sato; Shoko Ando

Return

Factors Related to Gemcitabine-induced Phlebitis

VernacularTitle:Factors Related to Gemcitabine-induced Phlebitis
Author: Akiko UNESOKO ¹ ; Akio KOHNO ² ; Nobukazu TOMITA ³ ; Kiyoshi ISHIGURE ⁴ ; Ayumi SUGIMURA ⁵ ; Kazuki SATO ⁵ ; Shoko ANDO ⁵
Author Information

1. Department of Nursing, Konan Kosei Hospital
2. Department of Hematology and Oncology, Konan Kosei Hospital
3. Department of Pharmaceutical, Konan Kosei Hospital
4. Department of Surgical, Konan Kosei Hospital
5. Fundamental and Clinical Nursing, Department of Nursing, Nagoya University Graduate School of Medicine
Keywords: Gemcitabine; phlebitis; related factor
From:Palliative Care Research 2018;13(2):187-193
CountryJapan
Language:Japanese
Abstract: Objective: The purpose of this study was to clarify the factors related to gemcitabine (GEM)-induced phlebitis. Methods: We retrospectively analyzed 400 cases of intravenous GEM administration to 50 patients from June 2014 to May 2015. We assessed the relationship between GEM-induced phlebitis and various factors including age, sex, BMI, analgesic use (NSAIDs or opioids), and GEM-administration procedures including drug formulation, dosage, and access site. Results: Phlebitis occurred in 79 cases (19.8%). Multivariate analysis indicated that sex (female), age (<65 years old), BMI (≥25 kg/m2; obesity), drug formulation (liquid), and access site (dorsal hand vein) were significantly related to the presence of phlebitis. Discussion: GEM-administration procedures should be modified in patients with these risk factors. It is desirable to apply hot fomentation and to puncture at the brachial region or cubital fossae region vein to prevent phlebitis.