Ideal lifestyles against colorectal tumorigenesis: with explanation for the impact of exercise or obesity on colorectal tumor development

VernacularTitle:Ideal lifestyles against colorectal tumorigenesis: with explanation for the impact of exercise or obesity on colorectal tumor development
Author: Michihiro MUTOH ¹ ; Shuya TAMURA ¹ ; Takahiro HAMOYA ¹ ; Gen FUJII ²
Author Information

1. Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center
2. Central Radioisotope Division, National Cancer Center Research Institute
Keywords: colorectal cancer; inflammation; life style; obesity; physical activity
From:Japanese Journal of Physical Fitness and Sports Medicine 2018;67(2):141-146
CountryJapan
Language:Japanese
Abstract: Obesity-associated cancers, including colorectal cancer, are increasing in Japan with Westernized lifestyles as exemplified by reduced physical activity and increased high-fat diet. An excessive accumulation of visceral adipose tissue causes insulin resistance, oxidative stress and adipocytokine imbalance, and these factors are suggested to be involved in colorectal tumorigenesis. In this review article, we focus on the relationships between each of the individual associated conditions, especially obesity and exercise, and colorectal tumor development with targeting molecules revealed by in vivo and in vitro studies. Furthermore, the potential for colorectal cancer prevention by targeting these molecules is discussed.