Two Cases of Ulcerative Colitis with Adjusted Tacrolimus by Daily Therapeutic Drug Monitoring
- VernacularTitle:連日血中濃度測定によりタクロリムスを調整した潰瘍性大腸炎の2症例
- Author:
Masahide SUGIYAMA
1
;
Yutaka AOKI
1
;
Keisuke SHINOHARA
1
;
Tomoaki MIYATA
1
;
Hirotaka SEKIGUCHI
1
Author Information
- From:Journal of the Japanese Association of Rural Medicine 2018;67(4):512-
- CountryJapan
- Language:Japanese
- Abstract: It is suggested that in the use of tacrolimus for treatment of ulcerative colitis, it is important to achieve and maintain a high trough level as soon as possible. We examined two cases, with a starting initial dose higher than that recommended in the package insert, and adjusted the dose by daily therapeutic drug monitoring. Improvement of symptoms was observed by maintaining a high trough level of 10 to 15 ng/mL in these 2 cases. This improvement was observed from 9 days after achieving the high trough level, and it took the same number of days as stated in the mode of administration in the package insert.
