The Effectiveness of Byakkokaninjinto Added Gypsum Powder in 12 Patients with Atopic Dermatitis Refractory to Treatment Including Steroid Repellents

Atsushi Yamamoto; Tomoe Fukunaga; Atsushi Niizawa; Nobukazu Horie; Saori Yonetani; Michiko Nagahama; Susumu Fujiwara; Yozo Yamada; Atsushi Fukunaga; Chikako Nishigori

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The Effectiveness of Byakkokaninjinto Added Gypsum Powder in 12 Patients with Atopic Dermatitis Refractory to Treatment Including Steroid Repellents

VernacularTitle:ステロイド忌避を含む難治性アトピー性皮膚炎12症例への白虎加人参湯エキス加石膏末使用から解析した有用性と使用目標
Author: Atsushi YAMAMOTO ¹ ; Tomoe FUKUNAGA ² ; Atsushi NIIZAWA ² ; Nobukazu HORIE ³ ; Saori YONETANI ² ; Michiko NAGAHAMA ⁴ ; Susumu FUJIWARA ² ; Yozo YAMADA ⁵ ; Atsushi FUKUNAGA ⁵ ; Chikako NISHIGORI ⁵
Author Information

1. Department of Dermatology, National Hospital Organization Kobe Medical Center
2. Department of Japanese Oriental Medicine, Kobe Century Memorial Hospital
3. Department of Palliative Care Medicine, Japanese Red Cross Society Himeji Hospital
4. Niizawa Internal Medicine and Kampo Clinic
5. Department of Dermatology, Kobe Century Memorial Hospital
Keywords: byakkokaninjinto; gypsum powder; atopic dermatitis; steroid repellents
From:Kampo Medicine 2018;69(2):133-139
CountryJapan
Language:Japanese
Abstract: We prospectively studied the effectiveness of byakkokaninjinto added gypsum powder for the treatment of atopic dermatitis (AD) by using the skin disease severity score, visual analogue scale (VAS) score for assessing itch severity, and Skindex-16 for assessing the quality of life (QOL) in 12 patients who were refractory to conventional treatments including steroid repellents. In addition, we retrospectively investigated for what types of “sho” (Kampo diagnosis) and eruptions this treatment was more effective. The results showed that the skin disease severity score and Skindex-16 significantly improved in 4 weeks. There was no significant improvement in eosinophil counts, IgE antibody levels, thymus and activation-regulated chemokine levels. Byakkokaninjinto added gypsum powder was found to be effective for the “sho” of “sensitive to heat” and “excessive sweating.” Thus, it can be one of the options in oral medicine for treating patients with intractable AD including steroid repellents because the rash improved in a short period of 4 weeks in our patients.