Effect of Coix-seed Reactive Derivatives (CRD) on Skin Pigmentation: A Randomized Controlled Trial

VernacularTitle:Coix-seed Reactive Derivatives (CRD)の皮膚色素沈着に与える影響に関する研究
Author: Nobutaka SUZUKI ¹ ; Takuya KAWASHIMA ² ; Hoko KYO ¹ ; Kazuo UEBABA ³
Author Information

1. Department of Complementary and Alternative Medicine Clinical Research and Development, Kanazawa University Graduate School of Medical Science
2. Aozora Dermatology Clinic
3. Teikyo Heisei University
Keywords: Coix lacryma-jobi L. var. ma-yuen Stapf; skin; pigmentation; 紅斑; randomized controlled trial
From:Japanese Journal of Complementary and Alternative Medicine 2018;15(2):85-90
CountryJapan
Language:Japanese
Abstract: We evaluated the effects of the extract of Coix-seed Reactive Derivatives (CRD) on female skin pigmentation. Ninety females with facial pigmentation were assigned randomly to 3 groups and CRD (2g/day, 4g/day or placebo) was administrated for 8weeks. We confirmed the safety of CRD, and both the rate of change of facial pigmentation and erythema in 4g/day group decreased significantly (p<0.01). Further studies are needed to define the optimal dose of CRD.