The Short-term Results of Photodynamic Therapy for Choroidal Neovascularization.
- Author:
Seoung Ho YOUN
1
;
Jeong Hee LEE
;
Hyung Chan KIM
Author Information
1. Department of Ophthalmology, Kangnam Sacred Heart Hospital, College of Medicine, Hallym University, Seoul, Korea. eyekim@netsgo.com
- Publication Type:Original Article
- Keywords:
Non-thermal diode laser;
Photodynamic therapy;
Subfoveal CNV;
Visudyne(R);
Visual acuity decrease
- MeSH:
Body Surface Area;
Choroid*;
Choroidal Neovascularization*;
Female;
Follow-Up Studies;
Humans;
Korea;
Lasers, Semiconductor;
Male;
Photochemotherapy*;
Retreatment;
Visual Acuity
- From:Journal of the Korean Ophthalmological Society
2001;42(12):1712-1720
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To evaluate the short-term results of photodynamic therapy with Verteporfin for the patients with choroidal neovascularization. METHODS: We performed photodynamic therapy with Verteporfin in 19 patients (19 eyes) who were diagnosed as subfoveal CNV. The range of age was from 27 to 81 years, and 57 years on average. Twelve patients were male and seven were female. The pretreatment visual acuity with ETDRS chart was from 20/200 to 20/32. On FAG, predominantly classic type were fourteen eyes, minimally classic were four eyes, and no classic was one eye. Visudyne(R) of 6 mg per body surface area was infused intravenously for 10 minutes, and then non-thermal diode laser of 689 nm wavelength was applied for 83 seconds with 600 Mw/Cm2 intensity. We followed up 1 month, 3 months after treatment, thereafter every 3 months. The follow up period was ranged from 3 months to 11 months, 4 months on average. We performed retreatment with the same method when any leakage was found on FAG which is performed every 3 month. RESULTS: Threes months after treatment, only one eye showed visual acuity decrease of more than 3 lines with ETDRS chart, and mean visual acuity change was increased by 0.94 lines. At the same time there was one eye which presented no leakage on FAG, seven eyes showed minimal leakage, ten eyes showed moderate leakage, and only one eye showed progression. Out of twelve eyes which could be followed up more than 6 months, only eye showed decreased visual acuity of more than 3 lines. On FAG, no leakage was not found, minimal leakage in nine eyes, moderate leakage in two eyes and one eye showed progression. CONCLUSION: The above results indicates that the short-term results of photodynamic therapy for subfoveal CNV from various causes were encouraging as a good treatment modality to reduce the risk of visual loss and further study with longer follow-up and large number of cases will be necessary to decide the effect of photodynamic therapy in Korea.
