Polymorphisms of MICA gene and their linkage disequilibrium with HLA-B among ethnic Han Chinese from Shenzhen.
- VernacularTitle:深圳地区汉族献血人群MICA等位基因多态性及其与HLA-B基因的连锁不平衡分析
- Author:
Songxing WANG
1
;
Yunping XU
;
Liumei HE
;
Wenxu HONG
;
Suqing GAO
Author Information
- Publication Type:Journal Article
- From: Chinese Journal of Medical Genetics 2018;35(5):747-752
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the distribution of MICA alleles among ethnic Han Chinese blood donors from Shenzhen and their linkage disequilibrium with HLA-B gene.
METHODSFor 143 randomly selected blood donors, the MICA and HLA-B alleles were determined with a PCR-sequence based typing (SBT) method. Allelic frequency, haplotypic diversity and linkage disequilibrium were analyzed with a Pypop software.
RESULTSThirteen MICA and 35 HLA-B alleles were identified among the 143 blood donors, among which MICA*008:01 had the highest frequency (76/286), whilst MICA*008:01-HLA-B*40:01 and MICA*010-HLA-B*46:01 were the most common haplotypes. No novel allele was identified.
CONCLUSIONThe allele frequencies, haplotype diversities and linkage disequilibrium parameters under a high resolution can facilitate further studies and applications of the MICA and HLA-B genes.
