Research Progress on Reversing Multidrug Resistance in Tumors by Using Chinese Medicine.
10.1007/s11655-018-2910-1
- Author:
Huan-Dong ZHAO
1
;
Hong-Juan XIE
2
;
Jian LI
1
;
Cai-Ping REN
3
;
Yu-Xiang CHEN
4
Author Information
1. Key Laboratory of Nanobiological Technology of Chinese Ministry of Health, Xiangya Hospital, Central South University, Changsha, 410008, China.
2. Department of Pharmacy, Tongren Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, 200336, China.
3. Cancer Research Institute, Collaborative Innovation Center for Cancer Medicine, Key Laboratory for Carcinogenesis of Chinese Ministry of Health, School of Basic Medical Science, Central South University, Changsha, 410078, China.
4. School of Pharmacy, Central South University, Changsha, 410013, China. Chenyx008@aliyun.com.
- Publication Type:Journal Article
- Keywords:
Chinese medicine;
multidrug resistance;
reversal agents;
tumor
- MeSH:
Drug Resistance, Multiple;
drug effects;
Drug Resistance, Neoplasm;
drug effects;
Drugs, Chinese Herbal;
pharmacology;
Humans;
Plant Extracts;
pharmacology;
Research
- From:
Chinese journal of integrative medicine
2018;24(6):474-480
- CountryChina
- Language:English
-
Abstract:
Multidrug resistance (MDR) is a major cause of cancer chemotherapy failure, and it is important to develop suitable reversal agents to overcome MDR. A majority of chemical reversal agents have acceptable reversal effects. However, the toxicity and adverse reactions associated with these agents restricts their clinical use. Chinese medicines (CMs) have lower toxicities and adverse reactions and are associated with multiple components, multiple targets and reduced toxicity. CMs have several advantages and could reverse MDR, decrease drug dosage, enhance patient compliance and increase efficacy. This review summarizes the current progress of CM reversal agents..
