Association of rs659366 polymorphisms with the outcomes of patients after surgery for colorectal cancer.

Yanqi Jiang; Yalan Yang; Ting Yang; Yueling LI; Liling Chen; Jin Yan; Yanfang Yang

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Association of rs659366 polymorphisms with the outcomes of patients after surgery for colorectal cancer.

Author: Yanqi JIANG ¹ ; Yalan YANG ¹ ; Ting YANG ¹ ; Yueling LI ² ; Liling CHEN ³ ; Jin YAN ⁴ ; Yanfang YANG ¹
Author Information

1. Department of Epidemiology and Biostatistics, West China School of Public Health, Sichuan University, Chengdu 610041, China.
2. Department of Infectious Disease Control and Prevention, Chengdu Center for Disease Control and Prevention, Chengdu 610041, China.
3. Institute for Chronic Non-communicable Disease Control and Prevention, Chongqing Center for Disease Control and Prevention, Chongqing 400042, China.
4. Department of Intestinal Surgery, Sichuan Cancer Hospital, Chengdu 610041, China.
Publication Type:Journal Article
MeSH: Colorectal Neoplasms; Genotype; Humans; Polymerase Chain Reaction; Polymorphism, Genetic; Proportional Hazards Models; Survival Rate; Uncoupling Protein 2
From: Journal of Zhejiang University. Medical sciences 2018;47(2):143-149
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo explore the association between rs659366 polymorphisms and the outcomes of patients after surgery for colorectal cancer.
METHODSThe study was conducted among a cohort of 501 patients with primary colorectal cancer who had surgery in Sichuan Cancer Hospital during March 2010 and July 2013. The outcomes of the patients were followed up. The polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was applied to detect rs659366 genotypes. The log-rank test was performed to analyze the effects of clinical features on patients' outcomes. The correlation between rs659366 polymorphisms and the outcomes of patients was analyzed using the Cox proportional hazard model.
RESULTSIn this study, the median of follow-up time was 44.23(0.13-78.53)months, and 101 out of 501 (20.2%) patients failed to follow-up. The log-rank test showed the tumor site, TNM stage, vascular invasion, perineural invasion and the preoperative carcino-embryonic antigen(CEA) level were significantly associated with the outcome of colorectal cancer (<0.05 or <0.01). The overall survival rate of patients with AA, GA and GG genotypes were 62.7%, 69.9% and 75.5%, respectively. Multivariate analysis according to Cox proportional hazard model taking the GG genotype as the reference indicated that the AA genotype increased risks for survival of patients (=1.823); under the dominant genetic model taking GG genotype as reference, GA+AA genotypes increased risks for the poorer outcomes of patients (=1.498); the addictive genetic model showed that allele A increased the hazard for the poorer outcomes (=1.787).
CONCLUSIONSThe rs659366 polymorphisms are significantly associated with the outcome of patients with colorectal cancer.