Molecular mechanisms underlying daptomycin resistance.

Author: Guojian LIAO ¹ ; Xixi PENG ¹ ; Jun TIAN ¹ ; Jianping XIE ²
Author Information

1. Institute of Modern Biopharmaceuticals, School of Pharmaceutical Sciences, Southwest University, Chongqing 400716, China.
2. State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, Institute of Modern Biopharmaceuticals, School of Life Sciences, Southwest University, Chongqing 400715, China.
Publication Type:Journal Article
Keywords: cell wall homeostasis; daptomycin; drug resistance; phospholipid metabolism
From: Chinese Journal of Biotechnology 2018;34(6):832-838
CountryChina
Language:Chinese
Abstract: Due to potent bactericidal activity and low rate of drug-resistance, daptomycin is recognized as first line antibiotic to treat serious infections caused by drug-resistant Gram-positive pathogens. However, the incidence of daptomycin resistance is increasing due to its widespread application. Alteration of cell wall homeostasis and membrane phospholipid metabolism is involved in daptomycin resistance. The unique mode of action underlying daptomycin resistance in important pathogens, including Staphylococcus aureus and Enterococci, is presented in this paper.