Advances in haplotype analysis technique.

Author: Shuangshuang LI ¹ ; Yingxin ZHANG ² ; Chengming FAN ² ; Yuhong CHEN ² ; Chuanliang DENG ¹ ; Zanmin HU ²
Author Information

1. College of Life Sciences, Henan Normal University, Xinxiang 453007, Henan, China.
2. Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China.
Publication Type:Journal Article
Keywords: direct experimental method; haplotype; haplotype analysis technique; haplotype assemblies; indirect computational inferential method
From: Chinese Journal of Biotechnology 2018;34(6):852-861
CountryChina
Language:Chinese
Abstract: Haplotype is the combination of a series of genetic mutations that coexist on a single chromosome, each of which has its own unique haplotypes. As a common data analysis method, the analysis of haplotype is effective for the localization of heterozygosis SNPs on single chromosome, the excavation of disease genes and the search of maladies treatments. It mainly includes indirect computational inferential method and direct experimental method. In this review we introduced various haplotype analysis methods and applications, especially two important ones: single-molecule dilution and contiguity-preserving transposition sequencing common technology. Meanwhile, further research prospects on haplotype sequencing were proposed.