Bottlenecks and modification strategies of 1,3-propanediol biosynthesis from glycerol.

Author: Miaomiao YANG ¹ ; Junhua YUN ¹ ; Huanhuan ZHANG ¹ ; Guoyan ZHANG ¹ ; Hossain ZABED ¹ ; Xianghui QI ¹
Author Information

1. School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, Jiangsu, China.
Publication Type:Journal Article
Keywords: 1,3-propanediol; bioconversion; biosynthesis; genetic engineering; glycerol
From: Chinese Journal of Biotechnology 2018;34(7):1069-1080
CountryChina
Language:Chinese
Abstract: Crude glycerol is the main by-product of biodiesel production. A few microorganisms can transfer crude glycerol to 1,3-propanediol (1,3-PD) that is an important chemical material. There exist many limitations such as substrate inhibition, product inhibition when wild strains are used in 1,3-PD biosynthesis. In this review, based on the microbial transformation of 1,3-propanediol from glycerol and its limitations, some strategies using genetic engineering such as knockout or gene overexpression were summarized. The latest research progresses in biosynthesis of 1,3-propanediol from glycerol by genetically engineered strains are discussed.