Post-translational modification and regulatory network of Mycobacterium tuberculosis antibiotic resistance.

Author: Longxiang XIE ¹ ; Yifang DANG ¹ ; Jianping XIE ²
Author Information

1. Institute of Biomedical Informatics, Basic Medical School, Henan University, Kaifeng 475004, Henan, China.
2. Institute of Modern Biopharmaceuticals, School of Life Sciences, Southwest University, Chongqing 400715, China.
Publication Type:Journal Article
Keywords: Mycobacterium tuberculosis; antibiotic; antibiotic resistance; posttranslational modifications
From: Chinese Journal of Biotechnology 2018;34(8):1279-1287
CountryChina
Language:Chinese
Abstract: Currently, there are many studies on the mechanism of antibiotic resistance in Mycobacterium tuberculosis (Mtb), but there are few studies on its regulatory mechanism. Post-translational modifications (PTMs) have been recognized for their important role in controlling cellular dynamics such as metabolism and stress response, but the relationship between PTMs and antibiotic resistance gradually attracted the attention of researchers. Here, we summarize the definition of PTMs, and the mechanisms of antibiotic resistance in M. tuberculosis and discuss how PTMs are involved in antibiotic resistance, in order to provide a new breakthrough for the development of new anti-Ttb drugs.