Progress in regulatory mechanism for inducing β-lactamase in Gram-negative bacteria.

Author: Chaoyi XU ¹ ; Ting ZHANG ¹ ; Jingxiao CAI ¹ ; Zhiliang YU ¹ ; Juanping QIU ¹ ; Jianhua YIN ¹
Author Information

1. College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310014, Zhejiang, China.
Publication Type:Journal Article
Keywords: Gram-negative bacteria; regulatory mechanism; two-component system; β-lactam antibiotics; β-lactamase
From: Chinese Journal of Biotechnology 2018;34(8):1288-1296
CountryChina
Language:Chinese
Abstract: Beta-lactams are the most widely used antibiotics. One of the principle mechanisms for Gram-negative bacteria to resist β-lactams is by producing β-lactamases that degrade β-lactams. This review highlights two regulatory mechanisms for inducing β-lactamase in Gram-negative bacteria. In the ampR-ampC paradigm, the induction of β-lactamase is intimately linked to peptidoglycan recycling. AmpR, a LysR-type transcriptional regulator, plays a central role in regulating expression of β-lactamase. Recent studies found that two-component signal transduction pathway is activated by β-lactams, which in turn induces the expression of β-lactamase. Finally, we discussed the future research directions in β-lactam resistance in Gram-negative bacteria.