Progress in Newcastle disease virus against tumor.

Author: Beibei WANG ¹ ; Lili SONG ¹ ; Dehui MA ¹ ; Yanxin DONG ¹ ; Xueli WANG ¹
Author Information

1. Animal Science and Technology College, Inner Mongolia University For the Nationalities, Tongliao 028042, Inner Mongolia, China.
Publication Type:Journal Article
Keywords: Newcastle disease virus; autophagy; oncolytic effect; tumor gene therapy
From: Chinese Journal of Biotechnology 2018;34(9):1432-1441
CountryChina
Language:Chinese
Abstract: Newcastle disease virus is paramyxoviridae, Avian mumps virus genus type I, and infects more than 250 species of birds, causing huge losses on poultry farming worldwide. Numerous experiments have demonstrated that Newcastle disease virus has oncolytic activity on tumor cells and can selectively replicate in cancer cells. Thus, Newcastle disease virus is a potential therapeutic agent for cancer treatment. Some human clinical trials achieved good results. In this review, we summarized research progress of the relationship between the structural protein of Newcastle disease virus and virulence, anti-tumor and autophagy of Newcastle disease.