Application and development of spectral network cluster method in post-translational modifications of identification peptides.

Author: Mingmin HE ¹ ; Kunxian SHU ¹ ; Mingze BAI ¹ ; Rui XU ¹
Author Information

1. Chongqing University of Posts and Telecommunications, Institute of Biological Information, Chongqing 400065, China.
Publication Type:Journal Article
Keywords: peptide identification; post-translational modifications; spectral library; spectral network
From: Chinese Journal of Biotechnology 2018;34(10):1567-1578
CountryChina
Language:Chinese
Abstract: Mass spectrometry and database searching are necessary to identify proteins and peptides. With the rapid development of mass spectrometry technology, mass spectrometry data in proteomics are acquired very quickly, providing a powerful method to identify large-scale proteins and peptides, making mass spectrometry data-based proteomics research more and more into the mainstream. The traditional database searching method has many limitations to identify post-translational modifications of peptides. This paper systematically reviews the development, theoretical concept and applications of spectral network method, and the advantages of spectral network library to identify peptides.