Review of high-resolution peripheral quantitative computed tomography for the assessment of bone microstructure and strength.

Jianxiong MA; Jie Zhao; Weiwei HE; Mingjie Kuang; Hengting Chen; Lukai Zhang; Lei Sun; Yuhong Cui; Xinlong MA; Ying Wang

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Review of high-resolution peripheral quantitative computed tomography for the assessment of bone microstructure and strength.

Author: Jianxiong MA ^{1
,

2
,

3} ; Jie ZHAO ^{2
,

3} ; Weiwei HE ^{2
,

3} ; Mingjie KUANG ^{2
,

3} ; Hengting CHEN ^{2
,

3} ; Lukai ZHANG ^{2
,

3} ; Lei SUN ^{2
,

3} ; Yuhong CUI ⁴ ; Xinlong MA ^{2
,

3} ; Ying WANG ^{2
,

3}
Author Information

1. School of Mechanical Engineering, Tianjin University, Tianjin 300072, P.R.China
2. Orthopaedics Institute, Tianjin Hospital, Tianjin 300211, P.R.China
3. Orthopaedics Institute, Tianjin University Tianjin Hospital, Tianjin 300211, P.R.China.
4. School of Mechanical Engineering, Tianjin University, Tianjin 300072, P.R.China.
Publication Type:Journal Article
Keywords: bone density; bone microstructure; bone strength; high-resolution peripheral quantitative computed tomography
From: Journal of Biomedical Engineering 2018;35(3):468-474
CountryChina
Language:Chinese
Abstract: Trabecular microstructure is an important factor in determining bone strength and physiological function. Normal X-ray and computed tomography (CT) cannot accurately reflect the microstructure of trabecular bone. High-resolution peripheral quantitative computed tomography (HR-pQCT) is a new imaging technique in recent years. It can qualitatively and quantitatively measure the three-dimensional microstructure and volume bone mineral density of trabecular bone . It has high precision and relative low dose of radiation. This new imaging tool is helpful for us to understand the trabecular microstructure more deeply. The finite element analysis of HR-pQCT data can be used to predict the bone strength accurately. We can assess the risk of osteoporosis and fracture with three-dimensional reconstructed images and trabecular microstructure parameters. In this review, we summarize the technical flow, data parameters and clinical application of HR-pQCT in order to provide some reference for the popularization and extensive application of HR-pQCT.