Research progress on preventions of ischemia-reperfusion injury during kidney transplant.
10.7507/1001-5515.201804009
- Author:
Lina GONG
1
;
Kunjie WANG
2
,
3
Author Information
1. Department of Urology Institute, West China Hospital, Sichuan University, Chengdu 610041, P.R.China.
2. Department of Urology Institute, West China Hospital, Sichuan University, Chengdu 610041, P.R.China
3. Department of Urology, West China Hospital, Sichuan University, Chengdu 610041, P.R.China.
- Publication Type:Journal Article
- Keywords:
ischemia-reperfusion injury;
kidney transplant;
renoprotection
- From:
Journal of Biomedical Engineering
2018;35(5):817-821
- CountryChina
- Language:Chinese
-
Abstract:
During kidney transplant, the non-specific inflammatory response induced by ischemia-reperfusion injury (IRI) will lead to decreased survival ability of transplanted kidney. However, the effect of IRI on long-term survival rate of allograft is not sure. Here we illuminated the relationship between early IRI and decreased long-term survival ability of allograft by retrospectively analyzing the clinical evidences and laboratory investigations. Previous studies showed that early IRI resulted in the graft loss through reduction of renal functional mass, vascular injury, chronic hypoxia and subsequent fibrosis. IRI was also one of the main factors to induce dysfunction of transplanted kidney and acute rejection reaction, and to decrease the allograft survival. Therefore, it's better to substitute traditional methods with novel measures during kidney transplant which may relieve the renal IRI much better.
