Research progress on the involvement of nuclear receptor in regulating autophagy.
10.7507/1001-5515.201804028
- Author:
Lingjuan WU
1
;
Xiaoli XU
1
;
Jun LIN
1
;
Weiwen CAI
1
;
Liqun CHEN
1
Author Information
1. College of Biological Science and Engineering, Fuzhou University, Fuzhou 350108, P.R.China.
- Publication Type:Journal Article
- Keywords:
autophagy;
farnesoid X receptor;
nerve growth factor-induced gene B;
nuclear receptor;
retinoic acid receptor;
vitamin D receptor
- From:
Journal of Biomedical Engineering
2018;35(5):822-828
- CountryChina
- Language:Chinese
-
Abstract:
Nuclear receptors are transcriptional regulators involved in almost all biological processes such as cell growth, differentiation, apoptosis, substance metabolism and tumor formation, and they can be regulated by small molecules that bind to them. Autophagy is a special way of programmed cell death and it is a highly conserved metabolic process. Once autophagy defects or excessive autophagy occur, the disease will develop. In recent years, numerous studies have shown that nuclear receptors are related to autophagy. Therefore, this paper mainly reviews the research progress on nuclear receptors involved in the regulation of autophagy, and focuses on the mechanism of several nuclear receptors involved in the regulation of autophagy, aiming at understanding the molecular basis of how nuclear receptors participate in regulating autophagy, as well as providing possible ideas and strategies for the treatment of corresponding diseases.
