Preclinical study on adverse reactions of Xingnaojing injection.
10.19540/j.cnki.cjcmm.20180130.005
- Author:
Yan YI
1
;
Chun-Ying LI
1
;
Yong ZHAO
1
;
Chen PAN
1
;
Su-Yan LIU
1
;
Lian-Mei WANG
1
;
Yu-Shi ZHANG
1
;
Jia-Yin HAN
1
;
Jing-Zhuo TIAN
1
;
Ai-Hua LIANG
1
Author Information
1. State Key Laboratory of Innovative Natural Medicine and TCM Injections, Key Laboratory of Beijing for Identification and Safety of Chinese Medicine, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.
- Publication Type:Journal Article
- Keywords:
Xingnaojing injection;
allergic reactions;
pseudoallergenic substances;
pseudoallergic reactions
- From:
China Journal of Chinese Materia Medica
2018;43(13):2789-2795
- CountryChina
- Language:Chinese
-
Abstract:
In this study, different batches of Xingnaojing injection products were first selected for pseudoallergic mice test, and the results showed that after injection of 6.6-fold clinical dose Xingnaojing injection, the mice showed a slight pseudoallergic reaction, while other mice injected with other batches of injections showed no obvious pseudoallergic reaction. Therefore, it is preliminarily believed that this mice model can effectively indicate the risk of pseudoallergic reactions in the clinical application of Xingnaojing injections. In addition, by changing some of the processes, a high concentration of Xingnaojing injection was prepared for mice pseudoallergic test and guinea pig systemic allergy test. The results showed no significant type Ⅰ allergic reaction in guinea pigs. Mild pseudoallergic reactions occurred in mice after a 6.6-fold clinical dose injection. Therefore, it is considered that for sensitive or idiosyncratic people, the concentration of certain chemical components in Xingnaojing injection will increase after entering the body, which may increase the risk of pseudoallergic reaction. However, due to the limitations of test models, the risk of Xingnaojing injection to induce allergic reactions cannot be ruled out. Finally, by increasing the content of borneol and Tween and (or) sodium chloride in Xingnnaojing Injection and testing its pseudoallergic reactions, the results showed that the combination of these three ingredients may produce new trace sensitization substance and induce pseudoallergic reactions.
