Effect of Shenqi Dihuang decoction on inflammatory factor, renal function and microcirculation in patients with early diabetic nephropathy.
10.19540/j.cnki.cjcmm.2018.0050
- Author:
Ming-Rui WANG
1
;
Li-Hua YU
1
;
Ting-Ting WANG
1
;
Ye-Mei WANG
1
;
Ming-Xiang HAN
2
Author Information
1. Anhui University of Traditional Chinese Medicine, Hefei 230038, China.
2. First Affiliated Hospital of Anhui University of Traditional Chinese Medicine, Hefei 230031, China.
- Publication Type:Journal Article
- Keywords:
Shenqi Dihuang decoction;
deficiency of both Qi and Yin syndiome;
early diabetic nephropathy;
inflammatory factor;
microcirculation;
renal function
- From:
China Journal of Chinese Materia Medica
2018;43(6):1276-1281
- CountryChina
- Language:Chinese
-
Abstract:
To study the effect of Shenqi Dihuang decoction on inflammatory factor, renal function and microcirculation in patients with early diabetic nephropathy. A total of 205 cases of patient with early diabetic nephropathy treated in our hospital from March 2014 to April 2016 were selected and divided into two groups according to the admitted order, with 103 cases in clinical group and 102 in control group. Patients in control group were treated with melbine and captopril, which may be adjusted according to the clinical symptom. The clinical group was given Shenqi Dihuang decoction. Then the clinical efficady, inflammatory factors, renal function, endothelial function and hemorheology index were compared. Compared with 77.45% in the control group, the total effective rate of the clinical group was 92.23%. There was a significant increase (<0.05). The comparison of the values of IL-6, IL-8, TNF-α and CRP between the two groups before and after treatment showed significant differences. The values of inflammatory factors in treatment group were lower than in control group (<0.05). The comparison of the values of β2-MG, Cys-C and urine m-ALB between the two groups before and after treatment showed significant differences. The values of renal function in treatment group were lower than those in control group (<0.05). Compared with before treatment, ET-1 of the two groups after treatment decreased, while NO increased (<0.05). Compared with the control group, the value of ET-1 in patients of the experimental group was lower after treatment, while NO was higher (<0.05). The comparison of the values of whole blood viscosity, plasma viscosity, whole blood reduction viscosity, platelet aggregation rate and fibrinogen between the two groups before and after treatment showed significant differences. The value of hemorheology index in treatment group was lower than that in control group (<0.05). Shenqi Dihuang decoction has a better effect on patients with early diabetic nephropathy. It can significantly intervene with inflammatory response, reduce proteinuria, protect the renal function of patients, and improve the patient's vascular endothelial function and blood rheology, so as to make microcirculation to recover to the normal level.
