Molecular mechanism of Mylabris for colorectal cancer based on integrative pharmacology.
10.19540/j.cnki.cjcmm.20180115.003
- Author:
Lei YANG
1
;
Meng-Jiao LIU
2
;
Zhi-Guo ZHANG
1
;
Wen-Ming CHEN
1
;
Qin ZHANG
1
;
Lin OUYANG
1
;
Ping WU
3
Author Information
1. The First Hospital of Hunan University of Chinese Medicine， Zhang Zhiguo Heritage Studio Related to the Old Chinese Medicine Experts， Changsha 410007, China.
2. Hunan University of Chinese Medicine, Changsha 410208, China.
3. The First People's Hospital of Changde， Changde 415700, China.
- Publication Type:Journal Article
- Keywords:
Mylabris;
colorectal cancer;
internet-based computation platform
- From:
China Journal of Chinese Materia Medica
2018;43(7):1317-1322
- CountryChina
- Language:Chinese
-
Abstract:
At present, the disjointing situation is generally present between "systemic"and "local", "macro" and "micro", " process" and "activity evaluation" in the study of traditional Chinese medicine (TCM). An urgent task for the modernization of TCM is to establish new strategies and methods which can reflect the overall characteristics of TCM. The introduction of integrative pharmacology provided a feasible approach to solve the problem of the fragmentation of TCM. Internet-based computation platform method was adopted in this study to explore the active molecular mechanism of Mylabris in the treatment of colorectal cancer. Based on the analysis of the functional integration of internet-based computation platform V1.0 version software, the "core components-key target- main pathway" multidimensional network of Mylabris in treatment of colorectal cancer disease was constructed to explore the potential molecular mechanism of Mylabris in treatment of colorectal cancer from multiple perspectives. The results showed that Mylabris can treat the colorectal cancer and the mechanism might be associated with amino acid metabolism, NF-κB signaling pathway, immune system, endocrine system, nervous system, and chemokine signal transduction pathway, epithelial cell signaling in helicobacter pylori infection, T cell receptor signaling pathway, B cell receptor signaling pathway and so on.
