Pharmacodynamic evaluation and molecular mechanism research of Huanshao capsule on irregular menstruation.
10.19540/j.cnki.cjcmm.2018.0054
- Author:
Jian-Hui SUN
1
;
Hai-Ru HUO
1
;
Xiao-Qin LI
1
;
Hong-Mei LI
1
;
De-Huai QIN
2
;
Chun WU
2
Author Information
1. Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.
2. Chongqing Sanxia Yunhai Pharmaceutical Co., Ltd., Chongqin 404500, China.
- Publication Type:Journal Article
- Keywords:
Huanshao capsule;
estrogen;
follicule-stimulating hormone;
integrative pharmacology;
irregular menstruation;
molecular mechanism
- From:
China Journal of Chinese Materia Medica
2018;43(7):1373-1383
- CountryChina
- Language:Chinese
-
Abstract:
Huanshao capsule is widely used in irregular menstruation and has achieved a good effect. Huanshao capsule can promote gonad development in mice, significantly improve the ovarian index in mice, increase estrogen level and reduce FSH level in rats, inhibit the pain response induced by oxytocin and estrogen, inhibit writhing reaction induced by acetic acid pain in mice. Due to the complexity of traditional Chinese medical formula, the pharmacological mechanism of the treatment on the irregular menstruation of the Huanshao capsule is unclear. In this study, the internet-based computation platform (www.tcmip.cn）was used to explore the molecular mechanism of Huanshao capsule on the menstrual. The aim of this study was to find the molecular mechanism of Huanshao capsule in treating menstrual. In the study of the molecular mechanism of Huanshao capsule in the treatment of menstrual by using the internet-based computation platform, Huanshao capsule maybe treat the menstrual by the pathway of endocrine system, GnRH signal transduction pathway, estrogen signal transduction pathway, oxytocin signaling pathway, thyroid hormone signaling pathway, VEGF signaling pathway, FCεRI signaling pathway and purine metabolism and nucleotide metabolism. The early pharmacological study confirmed Huanshao capsule could increase the serum estradiol level and decrease follicle stimulating hormone level and the traditional Chinese medicine pharmacology coincide with the prediction result of internet-based computation platform which roles as the pathway of GnRH signaling pathway and estrogen signal transduction pathway. Other pathway needs further experimental verification.
