A new aurone with anti-inflammatory activity from Cleistocalyx operculatus flower buds.
- Author:
Wen-Jun LIU
1
;
Zhao-Liang LI
1
;
Ning-Bo CHENG
1
;
Yu-Mei HU
1
;
Zhao-Qing MENG
1
;
Zhen-Zhen SU
1
;
Biao YANG
1
;
Wen-Zhe HUANG
1
;
Zhen-Zhong WANG
1
;
Wei XIAO
1
Author Information
- Publication Type:Journal Article
- Keywords: Cleistocalyx operculatus flower buds; anti-inflammatory activity; aurone; chalcone; synthesis
- From: China Journal of Chinese Materia Medica 2018;43(7):1467-1470
- CountryChina
- Language:Chinese
- Abstract: A new compound(Z)-6-hydroxy-4-methoxy-5,7-dimethylaurone was isolated from Cleistocalyx operculatus flower buds. Its structure was identified by spectroscopic data including MS, ¹H-NMR, ¹³C-NMR HSQC and HMBC. A known compound, 2',4'-dihydroxy-6'-methoxy-3'5'-dimethylchalcone (DMC), was also isolated and identified,and used as material to synthesize (Z)-6-hydroxy-4-methoxy-5,7-dimethylaurone.Anti-inflammatory activities of the two compounds were tested . The results showed that (Z)-6-hydroxy-4-methoxy-5,7-dimethylaurone possesses much stronger PGE₂ inhibitory activity (IC₅₀ 6.12 nmol·L⁻¹) than the positive control ibuprofen （68.66 nmol·L⁻¹）.
