Preparation of astilbin amorphous nanosuspension and its evaluation.
10.19540/j.cnki.cjcmm.20180117.003
- Author:
Xiao-Han WANG
1
;
Rui-Na ZHONG
1
;
Bao-de SHEN
2
;
Cheng-Ying SHEN
2
;
Xiao LIU
1
;
Bo DAI
2
;
Hai-Long YUAN
2
Author Information
1. College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
2. Department of Pharmacy, Air Force General Hospital, PLA, Beijing 100142, China.
- Publication Type:Journal Article
- Keywords:
amorphous nanosuspension;
antisolvent precipitation;
astilbin;
in vitro release
- From:
China Journal of Chinese Materia Medica
2018;43(8):1626-1632
- CountryChina
- Language:Chinese
-
Abstract:
Astilbil nanosuspension (AT-NS) was prepared by an antisolvent precipitation method. The formula and process of AT-NS were optimized by the single factor experiment. AT-NS was prepared under the optimal conditions, and its morphology and crystallinity were characterized. In vitro release of AT-NS was also determined. The particle size of AT-NS stabilized by PVP K30 was (149±3) nm, and the polydispersity index (PDI) and stability index (SI) were 0.137±0.014 and 0.940±0.012, respectively. The results of SEM showed that AT-NS was spherical. Both XRD and DSC showed that AT was amorphous in nanosuspension. In the release test, AT-NS showed a significantly increased dissolution. This simple low-cost approach could prepare AT-NS successfully. AT-NS could significantly improve the dissolution of AT and provide the reference to break the limitation on the clinical application of AT.
