Relationships between Rapid Eye Movement Sleep Behavior Disorder and Neurodegenerative Diseases: Clinical Assessments, Biomarkers, and Treatment.
- Author:
Min LI
1
;
Li WANG
1
;
Jiang-Hong LIU
1
;
Shu-Qin ZHAN
1
Author Information
- Publication Type:Journal Article
- Keywords: Dementia with Lewy Bodies; Multiple System Atrophy; Neurodegenerative Disease; Parkinson's Disease; Rapid Eye Movement Sleep Behavior Disorder
- MeSH: Biomarkers; blood; Humans; Lysosome-Associated Membrane Glycoproteins; genetics; Neurodegenerative Diseases; blood; genetics; physiopathology; Parkinson Disease; blood; genetics; physiopathology; Polymorphism, Single Nucleotide; genetics; REM Sleep Behavior Disorder; blood; genetics; physiopathology; Receptors, Scavenger; genetics; tau Proteins; genetics
- From: Chinese Medical Journal 2018;131(8):966-973
- CountryChina
- Language:English
-
Abstract:
ObjectiveRapid eye movement sleep behavior disorder (RBD) is characterized by dream enactment and loss of muscle atonia during rapid eye movement sleep. RBD is closely related to α-synucleinopathies including Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy. Many studies have investigated the markers of imaging and neurophysiological, genetic, cognitive, autonomic function of RBD and their predictive value for neurodegenerative diseases. This report reviewed the progress of these studies and discussed their limitations and future research directions.
Data SourcesUsing the combined keywords: "RBD", "neurodegenerative disease", "Parkinson disease", and "magnetic resonance imaging", the PubMed/MEDLINE literature search was conducted up to January 1, 2018.
Study SelectionA total of 150 published articles were initially identified citations. Of the 150 articles, 92 articles were selected after further detailed review. This study referred to all the important English literature in full.
ResultsSingle-nucleotide polymorphisms in SCARB2 (rs6812193) and MAPT (rs12185268) were significantly associated with RBD. The olfactory loss, autonomic dysfunction, marked electroencephalogram slowing during both wakefulness and rapid eye movement sleep, and cognitive impairments were potential predictive markers for RBD conversion to neurodegenerative diseases. Traditional structural imaging studies reported relatively inconsistent results, whereas reduced functional connectivity between the left putamen and substantia nigra and dopamine transporter uptake demonstrated by functional imaging techniques were relatively consistent findings.
ConclusionsMore longitudinal studies should be conducted to evaluate the predictive value of biomarkers of RBD. Moreover, because the glucose and dopamine metabolisms are not specific for assessing cognitive cognition, the molecular metabolism directly related to cognition should be investigated. There is a need for more treatment trials to determine the effectiveness of interventions of RBD on preventing the conversion to neurodegenerative diseases.
