Clinical analysis of serotretine combined with metformin in the treatment of senile diabetic patients with sulfonylurea failure
10.3969/j.issn.1005-1678.2017.07.121
- VernacularTitle:西格列汀联合二甲双胍治疗磺脲类药物失效老年糖尿病患者临床分析
- Author:
Xin-xin ZHANG
;
Zi'an CHENG
;
- Keywords:
sitagliptin;
metformin;
sulfonylurea failure;
diabetes mellitus
- From:
Chinese Journal of Biochemical Pharmaceutics
2017;37(7):296-298
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical effect of sitagliptin combined with metformin in the treatment of sulfonylurea-deficient elderly patients with diabetes mellitus.Methods Sixty patients with diabetes mellitus were enrolled in our hospital from January 2013 to December 2016.The patients were divided into observation group(30 cases) and control group(30 cases) according to the random number method.The patients in the observation group were treated with sitagliptin and metformin.The patients in the control group were treated with gemcitabine, and the clinical treatment effect, fasting blood glucose, postprandial blood glucose, glycosylated hemoglobin, fasting C peptide and postprandial 2hC peptide Level of statistical comparison.Results The clinical effect of the observation group was significantly higher than that of the control group.Before and after treatment, the fasting blood glucose, 2h postprandial blood glucose, glycosylated hemoglobin, fasting C peptide and postprandial 2hC peptide level were not significantly different After fasting blood glucose, 2h postprandial blood glucose and glycosylated hemoglobin levels were significantly lower than before treatment, after treatment of fasting C peptide and postprandial 2hC peptide levels were significantly higher than before treatment.Conclusion The clinical efficacy of serotretine combined with metformin in the treatment of elderly patients with diabetes mellitus is similar to that of Yuxing, and the combination is more convenient and more suitable for clinical treatment.It is worthy to be popularized and applied in clinical practice.
