Rheological Properties and Retention Ability of Octoxynol-9 Vaginal Thermosensitive in Situ Gel
- VernacularTitle:辛苯聚醇阴道用温敏凝胶的流变学特性及缓释滞留性研究
- Author:
Ping YUAN
;
Ying CHEN
;
Li'na LIU
- Keywords:
Octoxynol-9;
Thermosensitive in situ gel;
Rheological properties;
Retention ability
- From:
China Pharmacist
2017;20(6):982-985
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To observe the rheological properties of octoxynol-9 vaginal thermosensitive in situ gel [(O-9)-VTG] for predicting the gelation behavior in vivo, and evaluate the retention ability in vagina.Methods: The rheological parameters of (O-9)-VTG and (O-9)-VTG diluted by stimulant vaginal fluid (SVF) were measured by a Haake Rheomix to characterize the rheological properties.The vaginal samples after the administration of self-made (O-9)-VTG and O-9 gel were withdrawn, and then the concentration of octoxynol-9 in the samples was determined to evaluate the retention ability.Results: (O-9)-VTG was Newtonian fluid with low viscoelasticity under room temperature and converted to gel at 32.6℃.The formula could still transform into gel at body temperature after diluted by SVF, and resided in the vagina of mice above 8 h.Conclusion: (O-9)-VTG has suitable gelation temperature and rheological properties.Compared with the self-made octoxynol-9 gel, (O-9)-VTG has satisfactory retention in vagina, which meets the requirements for vaginal topical use.
