Comparison of anterograde amnesia produced by midazolam, propofol and dexmedetomidine when used to supplement sedation during neuraxial anesthesia
10.3760/cma.j.issn.0254-1416.2017.04.020
- VernacularTitle:咪达唑仑、异丙酚及右美托咪定用于椎管内麻醉辅助镇静时顺行性遗忘作用的比较
- Author:
Aihua ZHAO
;
Ya'nan LI
;
Xiang LIU
;
Qi ZHANG
;
Xi XIN
;
Qiujun WANG
;
Xiuli WANG
;
Shuping HUO
;
- Keywords:
Midazolam;
Propofol;
Dexmedetomidine;
Amnesia,anterograde
- From:
Chinese Journal of Anesthesiology
2017;37(4):458-460
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the anterograde amnesia produced by midazolam,propofol and dexmedetomidine when used to supplement sedation during neuraxial anesthesia.Methods Sixty patients of both sexes,aged 18-50 yr,with body mass index of 23-26 kg/m2,of American Society of Anesthesiologists physical status Ⅰ or Ⅱ,scheduled for elective operation on lower limbs with neuraxial anesthesia,were divided into 3 groups (n =20 each) using a random number table:midazolam group (group M),propofol group (group P) and dexmedetomidine group (group D).When the height of anesthesia was kept below T10,midazolam in a loading dose of O.05 mg/kg was intravenously injected in group M,propofol in a loading dose of O.4 mng/kg was intravenously injected in group P,and dexmedetomidine in a loading dose of 0.6 μg/kg was intravenously injected in group D.The infusion rate of the 3 drugs was adjusted to maintain bispectral index value at 82-86.When Observer's Assessment of Alertness/Sedation Scale scores achieved 3 or 4 after administration,anterograde amnesia was measured by postoperative recall of cards.The development of intraoperative hypotension,bradycardia and respiratory depression was recorded.Results Compared with group M,the incidence of global amnesia was significantly decreased in P and D groups (P＜0.05).There was no significant difference in the incidence of global amnesia between group P and group D (P＞ 0.05).No patients developed hypotension,bradycardia or respiratory depression in three groups.Conclusion Midazolam produces better anterograde amnesia than propofol and dexmedetomidine when used to supplement sedation during neuraxial anesthesia.
