Effects of calcitriol supplementation on microalbuminuria and isletβcell function in patients with type 2 diabetes mellitus

VernacularTitle:补充骨化三醇对2型糖尿病患者尿微量白蛋白和胰岛β细胞功能的影响
Author: Wenjuan JIANG ; Jin'an ZHANG ;
Keywords: Type 2 diabetes mellitus; Calcitriol; Microalbuminuria; Islet βcell function
From: Clinical Medicine of China 2017;33(7):610-614
CountryChina
Language:Chinese
Abstract: Objective To observe the changes in blood glucose,albumin/creatinine ratio and isletβcell function,after calcitriol therapy was used on patients with type 2 diabetes mellitus and microalbuminuria.Methods Sixty patients with type 2 diabetic microalbuminuria were randomly divided into experimental group and control group,each had 30 cases.Patients in the experimental group were given calcitriol 0.25ug once a day for three months,the changes of blood glucose,glycosylated hemoglobin,albumin/creatinine ratio,islet βcell function were observed.Results After the intervention,the albumin/creatinine ratio level in the experimental group was lower than that in the control group ((127.48±139.94) mg/g vs.(151.02±96.25) mg/g,P=0.04).The insulin resistance index in the experimental group was lower than that in the control group ((2.99±1.24) vs.(3.72±2.58),P=0.233),the difference was not statistically significant.Conclusion Calcitriol can reduce microalbuminuria in patients with type 2 diabetes.Calcitriol may be helpful in improving insulin resistance in patients with type 2 diabetes mellitus.