Diffusion tensor imaging of neonates with hypoxic ischemic encephalopathy

VernacularTitle:扩散张量成像在新生儿缺氧缺血性脑病中的应用
Author: Xianglong LIU ; Xin ZHAO ; Xueyuan WANG ; Yichang XIAO ; Xiaoyan ZHAO ; Xiao'an ZHANG ;
Keywords: neonate; hypoxic ischemic encephalopathy; diffusion tensor imaging
From: Journal of Practical Radiology 2017;33(7):1084-1087
CountryChina
Language:Chinese
Abstract: Objective To explore the application of diffusion tensor imaging(DTI) in neonates with hypoxic ischemic encephalopathy(HIE).Methods 37 cases of full-term neonates diagnosed as HIE by pediatricians and 12 normal neonates were selected.All subjects underwent MRI and DTI at 3.0 Tesla.The correlation of FA value in posterior limb of internal capsule and neonatal NBNA score was examined.Results The FA values in posterior limb of internal capsule, splenium had significant difference between the HIE group (mild group, moderate group, severe group) and control group (P<0.05);in central white matter of the frontal lobe, thalamus had significant difference between HIE severe group and control group (P<0.05);in nucleus of the bean had no statistic difference between the HIE group (mild group, moderate group,severe group) and control group (P>0.05).The FA in posterior limb of internal capsule and NBNA score(12-14 d;26-28 d)showed significant correlation (r=0.96,P<0.05),as well as the sequelae shape (r=0.87,P<0.05).Conclusion DTI is promising for early diagnosis of anisotropic index changes to evaluate HIE brain damage and prognosis.