Effects of Levocarnitine on Peripheral Blood T Cell Subsets and Inflammatory Factors in Diabetic Patients Underwent Peritoneal Dialysis
10.6039/j.issn.1001-0408.2017.20.29
- VernacularTitle:左卡尼汀对糖尿病腹膜透析患者外周血T细胞亚群及炎症因子的影响
- Author:
Lurong YANG
;
Lin YANG
;
Zhixia SONG
;
Chuan'e HE
;
Lan MA
;
- Keywords:
Th1;
Th2;
T cell subsets;
Inflammatory factors;
Levocarnitine;
Peritoneal dialysis
- From:
China Pharmacy
2017;28(20):2837-2840
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the effects of levocarnitine on peripheral blood T cell subsets and inflammatory factors in diabetic patients underwent peritoneal dialysis. METHODS:A total of 100 diabetic patients underwent peritoneal dialysis in se-lected as research objects were divided into conventional therapy group and levocarnitine group according to random number table, with 50 cases in each group. Conventional therapy group received peritoneal dialysis and conventional therapy. Levocarnitine group was additionally given levocarnitine 1.0 g added into 0.9% Sodium chloride injection 20 mL intravenously,3 times a week,on the basis of conventional therapy group for 12 weeks. CD3+,CD4+,the proportion of Th1 and Th2,the contents of TNF-α,INF-γ, IL-10 and IL-4 in supernatant were all detected before and after treatment. The expression of T-bet and GATA-3 were compared be-tween 2 groups. RESULTS:After treatment,CD3+,CD4+,Th2 cells,GATA-3 expression and IL-10,IL-4 levels were significantly increased,the expression of Th1 cells,T-bet content and TNF-αand INF-γwere significantly reduced,and levcarnitine group was sig-nificantly better than conrentional therapy group,with statistically significant (P<0.05). CONCLUSIONS:Levocarnitine can im-prove inflammatory reaction and the expression of related transcription factors by promoting T cell subsets and Th1/Th2 cell subsets.
