Clinical significance of changes of serum CEA,SCC,CYFRA21-1 and NSE levels in patients with advanced lung cancer
10.3969/j.issn.1673-4130.2017.09.020
- VernacularTitle:晚期肺癌患者血清CEA、CYFRA21-1、SCC、NSE水平变化的临床意义
- Author:
Rongxing WEI
;
Yuanhuan LIU
;
Yu′e WEI
;
- Keywords:
lung cancer;
cancer embryo antigen;
cell keratin 19;
squamous cell carcinoma associated antigen;
neuron ron specific enolase;
chemotherapy
- From:
International Journal of Laboratory Medicine
2017;38(9):1211-1213
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the value of carcino embryonic antigen(CEA),carbohydrate antigen 19,cytokeratin(CYFRA21-1),squamous cell cancer antigen(SCC) and neuron specific enolase(NSE) for the evaluation of chemotherapy response in the patients with advanced lung cancer.Methods One hundred and thirty-six patients with advanced lung cancer(lung cancer group) and 40 patients with lung benign disease(control group) were collected.The lung cancer group was treated with at least two courses of chemotherapy.The CYFRA21-1,SCC,CEA and NSE levels before chemotherapy were compared among the lung cancer group,control group and the patients with different pathological types.The above mentioned tumor markers levels before and after chemotherapy were compared among the patients with different curative effects in the lung cancer group.Results The levels of serum NSE,CYFRA21-1,CEA and SCC before treatment in the lung cancer group were higher than those in the control group(P<0.01);the serum CEA level of the squamous carcinoma group was higher than that of the adenocarcinoma group and the small cell carcinoma group(P<0.01),and the serum NSE level of the small cell carcinoma group was higher than that of the adenocarcinoma and squamous cell carcinoma group(P<0.01),and the levels of CYFRA21-1 and SCC of the squamouscarcinoma group were higher than those of the adenocarcinoma and small cell groups(P<0.01).The serum CEA level of patial remission(PR) patients in adenocarcinoma group was significantly decreased(P<0.01),the serum SCC level of PR patients in the squamous cell carcinoma group was significantly decreased(P<0.05),and the serum NSE level of PR patients in small cell carcinoma group was significantly decreased after chemotherapy(P<0.01).The difference of serum NSE,CYFRA21-1 and SCC after chemotherapy in stnble and prosgoressive patients of various groups were not statistically significant(P>0.05).Conclusion CEA,CYFRA21-1,SCC and NSE can be used as the effective evaluation indexes of chemotherapy in lung adenocarcinoma,lung squamous cell carcinoma and small cell carcinoma,but which has little significance in the patients without effect of chemotherapy.
