Correlation between O-linked N-acetylglucosamine glycosylation modification and diabetic retinopathy
10.3760/cma.j.issn.1005-1015.2017.03.027
- VernacularTitle:O位N-乙酰葡萄糖胺糖基化修饰与糖尿病视网膜病变的相关性研究现状
- Author:
Yuan ZHANG
;
Kun LIU
;
Feng'e CHEN
;
- Keywords:
Diabetic retinopathy/etiology;
Acetylglucosamine;
Glycosylation;
Review
- From:
Chinese Journal of Ocular Fundus Diseases
2017;33(3):318-321
- CountryChina
- Language:Chinese
-
Abstract:
O-linked N-acetylglucosamine (O-GlcNAc) glycosylation is an important form of posttranslational protein modification,mainly intracellular.It is closely related to cellular signaling pathways,and is involved in signal transduction,gene transcription and other important biological processes.Studies have found that O-GlcNAc glycosylation is directly related with diabetic retinopathy (DR),further studies may help us to uncover the DR mechanism,and develop new strategies for the diagnosis and treatment of this disease.
