Research of IL-28B gene rs129798600 polymorphism in the treatment of HCV genotype 1 patients with early response

VernacularTitle:IL-28B基因 rs129798600多态性治疗 HCV基因型1患者早期应答的关系
Author: Jianping XU ; Yonghui KUANG ;
Keywords: HCV; polymorphism; interferon; ribavirin
From: International Journal of Laboratory Medicine 2016;37(23):3288-3289,3292
CountryChina
Language:Chinese
Abstract: Objective To explore the prediction of sustained virological response (SVR)in the patients with hepatitis C virus (HCV)genotype 1 based on the polymorphism of IL‐28B gene to provide scientific reference basis for the treatment of the patients . Methods the quantitative value of HCV was detected by fluorescence quantitative PCR method ,and the genotype of rs129798600 was detected by gene sequencing method .Results The age in the patients with cevr was significantly lower than that in the patients with no cevr(Non‐cEVR) ,while the male proportion and the level of ALT level were significantly higher than those in the latter ;IL‐28B genotype CC and age less than 40 years old were independent related factors of cEVR occurrence .Conclusion In the pa‐tients with HCV rs129798600 site CT genotype ,it can be considered that the PEG‐IFN combined RBV treatment is conducted in the patients aged less than 40 years old ,while the other patients could be treated by the triple therapy .