Research of relevant laboratory indexes of rheumatic heart disease
10.3969/j.issn.1673-4130.2016.14.009
- VernacularTitle:风湿性心脏病相关临床检验指标的研究
- Author:
Sitong ZHOU
;
Jianjun XUE
;
Yongsheng WANG
;
- Publication Type:Journal Article
- Keywords:
rheumatic heart disease;
markers of cardiac injury;
biochemical indexes
- From:
International Journal of Laboratory Medicine
2016;37(14):1923-1924,1927
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between the related indexes with rheumatic heart disease (RHD) and its clinical significance .Methods The medical records information in 236 patients with rheumatic fever caused cardiac were collected and divided into the RHD group ,simple rheumatic fever group and normal healthy control group .The levels of related indiexe such as Mb and cTnI were detected in the three groups .Results The Mb ,cTnI and CK‐MB and NT‐proBNP had statistical differences between the RHD group and simple rheumatic fever groups (P<0 .05);the levels of ESR ,RF ,CRP ,cTnI ,Mb ,CK‐MB ,CK and NT‐proBNP had statistically significant differences between the RHD group and healthy control group (P<0 .05);With the NT‐proB‐NP level of 136 .17 pg/mL as the critical value ,the sensitivity ,specificity ,positive predictive value and negative predictive value of NT‐proBNP for diagnosing RHD were 95 .48% ,90 .15% ,86 .7% and 97 .86% respectively .Conclusion The levels of blood cTnI , Mb and CK‐MB in the patients with RHD are significantly higher than those in the normal controls ,so detecting the serum NT‐proBNP concentration is a sensitive indicator for early diagnosis of RHD .
