Influence of donepezil hydrochloride and hyperbaric oxygen on cognitive function in patients with vascular dementia
10.3760/cma.j.issn.1008-6706.2016.15.017
- VernacularTitle:盐酸多奈哌齐联合高压氧对血管性痴呆患者认知功能的影响
- Author:
De′e MENG
;
Changdong HAO
;
- Publication Type:Journal Article
- Keywords:
Vascular dementia;
donepezil;
hyperbaric oxygen;
cognitive function
- From:
Chinese Journal of Primary Medicine and Pharmacy
2016;23(15):2301-2303,2304
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the influence of donepezil hydrochloride and hyperbaric oxygen on cognitive function in patients with vascular dementia.Methods 61 cases of patients with vascular dementia were chosen to research,and were divided into research group(31 cases)and control group(30 cases),the control group was treated with piracetam,the research group was treated with donepezil hydrochloride and hyperbaric oxygen,after 12 weeks of treatment congnitive function,daily life quality and adverse reaction between two group were compared. Results The ADL score and MMSE score between the two group had no significant difference before treatment(all P <0.05).The MMSE score of the research group were higher than the control group[(18.71 ±3.29)points vs (15.83 ±3.45)points]after treatment,the difference was statistically significant (t =3.337,P <0.05).The ADL score of the research group were lower than control group[(37.12 ±7.13)points vs (42.53 ±6.74)points],the difference was statistically significant (t =3.026,P <0.05).4 cases of mild to moderate earache and 1 case of mild diarrhea occurred in the research group,and 1 case of upper abdominal pain occurred in the control group,there was no significant difference in the incidence of adverse reactions between the two groups (χ2 =0.803,P >0.05 ). Conclusion Donepezil hydrochloride combined with hyperbaric oxygen could effectively improve the cognitive function of patients with vascular dementia,and with good safety.
